Covid-19: A New Study Discovers a Potential Factor Contributing To Disease Severity
New Delhi, India Scientists have identified a protein responsible for the virus in a recent study, shedding insight on a component that may play a crucial role in severe cases of Covid-19.
The protein was discovered by researchers from the University of Kent’s School of Biosciences and Goethe-Institute University’s of Medical Virology. The scientific journal Current Issues in Molecular Biology published the article titled ‘A possible involvement of the CD47-SIRPalpha axis in COVID-19 pathogenesis.’What are the results?
The coronavirus that causes Covid-19 is SARS-CoV-2. While many people develop either moderate or no symptoms after being infected with SARS-CoV-2, others suffer severe, life-threatening illnesses.
The researchers discovered that infected cells with SARS-CoV-2 had higher amounts of a protein called CD47 on the cell surface. CD47, also known as “do not eat me,” provides a signal to the immune system’s defences, preventing cells from being destroyed. According to ANI, viral-induced CD47 on the surface of infected cells protects them from immune system detection, allowing them to produce more virus and cause more severe illness.
in accordance withAccording to study, risk factors for severe Covid-19, such as older age and diabetes, are associated with greater CD47 levels.
In fact, the study found that elevated CD47 levels caused by ageing and viruses contribute to severe Covid-19 by limiting an efficient immune response and increasing disease-associated tissue and organ damage.
Because CD47-targeting treatments are being developed, this discovery might lead to better Covid-19 therapy.