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zyprexa dosage in elderly
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zyprexa dosage in elderly,Proper Use,Precautions,Side Effects Etc

zyprexa dosage in elderly Olanzapine is used to treat schizophrenia. It may also be used alone or with other medicines (e.g., lithium or valproate) to treat mania or mixed episodes that are part of bipolar disorder (manic-depressive illness). Olanzapine may also be used with fluoxetine to treat depression, which is a part of bipolar disorder, and depression in patients who received other antidepressants that did not work well. This medicine should not be used to treat behavioural problems in older adult patients with dementia or Alzheimer’s.

This medicine is available only with your doctor’s prescription.

This product is available in the following dosage forms:

  • Tablet, Disintegrating
  • Tablet
zyprexa dosage in elderly

zyprexa dosage in elderly Before Using

In deciding to use a medicine, the risks of taking medication must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or other medicines. Also, tell your health care professional if you have any different types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of olanzapine in children. However, the safety and efficacy of olanzapine alone in children younger than 13 years of age and the olanzapine and fluoxetine combination in children younger than 10 years of age have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of olanzapine in the elderly. However, elderly patients are more likely to have dementia or age-related liver, kidney, or heart problems, which may require caution or an adjustment in the dose for patients receiving olanzapine.

Breastfeeding

There are no adequate studies on women determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together, in other cases, two different treatments may be used together, even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When taking this medicine, your healthcare professional must know if you are taking any of the drugs listed below. The following interactions have been selected based on their potential significance and are not all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change to some other drugs.

  • Bepridil
  • Bromopride
  • Cisapride
  • Dronedarone
  • Levoketoconazole
  • Levomethadyl
  • Mesoridazine
  • Metoclopramide
  • Pimozide
  • Piperaquine
  • Potassium Citrate
  • Saquinavir
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Ziprasidone

Using this medicine with any of the following medicines is usually not recommended but may be required in some cases. If both medications are prescribed, your doctor may change the dose or how often you use one or both medicines.

  • Abametapir
  • Alfentanil
  • Alprazolam
  • Amiodarone
  • Amisulpride
  • Anagrelide
  • Apalutamide
  • Apomorphine
  • Aripiprazole
  • Aripiprazole Lauroxil
  • Arsenic Trioxide
  • Benzhydrocodone
  • Bromazepam
  • Bromocriptine
  • Buprenorphine
  • Bupropion
  • Buserelin
  • Butorphanol
  • Cabergoline
  • Calcium Oxybate
  • Cannabidiol
  • Capmatinib
  • Carbamazepine
  • Ceritinib
  • Cetirizine
  • Chloroquine
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clobazam
  • Clofazimine
  • Clomipramine
  • Clonazepam
  • Clothiapine
  • Clozapine
  • Codeine
  • Crizotinib
  • Dabrafenib
  • Daridorexant
  • Dasatinib
  • Degarelix
  • Delamanid
  • Deslorelin
  • Deutetrabenazine
  • Dexmedetomidine
  • Dihydrocodeine
  • Donepezil
  • Doxylamine
  • Efavirenz
  • Encorafenib
  • Enoxacin
  • Entrectinib
  • Enzalutamide
  • Escitalopram
  • Esketamine
  • Fenoldopam
  • Fentanyl
  • Fexinidazole
  • Fingolimod
  • Flibanserin
  • Fluconazole
  • Fluoxetine
  • Fluvoxamine
  • Formoterol
  • Foscarnet
  • Fosphenytoin
  • Fostemsavir
  • Gabapentin
  • Gabapentin enacarbil
  • Glasdegib
  • Glucagon
  • Glycopyrrolate
  • Glycopyrronium Tosylate
  • Gonadorelin
  • Goserelin
  • Histrelin
  • Hydrocodone
  • Hydromorphone
  • Hydroxychloroquine
  • Hydroxyzine
  • Inotuzumab Ozogamicin
  • Ivabradine
  • Ivosidenib
  • Ketamine
  • Ketoconazole
  • Lefamulin
  • Lemborexant
  • Lenvatinib
  • Leuprolide
  • Levocetirizine
  • Levodopa
  • Levofloxacin
  • Levorphanol
  • Lithium
  • Lofexidine
  • Loxapine
  • Lumacaftor
  • Macimorelin
  • Magnesium Oxybate
  • Meperidine
  • Methacholine
  • Methadone
  • Metronidazole
  • Milnacipran
  • Mirtazapine
  • Mitotane
  • Mobocertinib
  • Morphine
  • Morphine Sulfate Liposome
  • Moxifloxacin
  • Nafarelin
  • Nalbuphine
  • Nilotinib
  • Ondansetron
  • Osilodrostat
  • Osimertinib
  • Oxaliplatin
  • Oxycodone
  • Oxymorphone
  • Ozanimod
  • Pacritinib
  • Panobinostat
  • Pasireotide
  • Pazopanib
  • Pentazocine
  • Pergolide
  • Periciazine
  • Phenytoin
  • Pimavanserin
  • Pitolisant
  • Pixantrone
  • Ponesimod
  • Posaconazole
  • Potassium Oxybate
  • Pramipexole
  • Pregabalin
  • Quetiapine
  • Remifentanil
  • Remimazolam
  • Revefenacin
  • Ribociclib
  • Rifampin
  • Ropeginterferon Alfa-2b-njft
  • Ropinirole
  • Rotigotine
  • Scopolamine
  • Secretin Human
  • Selpercatinib
  • Sertraline
  • Sevoflurane
  • Siponimod
  • Sodium Oxybate
  • Solifenacin
  • Sotalol
  • St John’s Wort
  • Sufentanil
  • Sulpiride
  • Sunitinib
  • Tacrolimus
  • Tapentadol
  • Tetrabenazine
  • Tiotropium
  • Tramadol
  • Trazodone
  • Triclabendazole
  • Triptorelin
  • Vandetanib
  • Vemurafenib
  • Vinflunine
  • Voclosporin
  • Zolpidem
  • Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medications are prescribed, your doctor may change the dose or how often you use one or both medicines.

  • Amprenavir
  • Betel Nut
  • Fosamprenavir
  • Haloperidol
  • Ritonavir
  • Valproic Acid

Other Interactions

Certain medicines should not be used at or around the time of eating or certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected based on their potential significance and are not all-inclusive.

Using this medicine with any of the following is usually not recommended but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine or give you special instructions about using food, alcohol, or tobacco.

  • Tobacco

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Blood vessel disease or circulation problems or
  • Dehydration or
  • Heart attack or stroke, history of or
  • Heart disease or
  • Heart failure or
  • Heart rhythm problems or
  • Hypotension (low blood pressure) or
  • Hypovolemia (low blood volume)—This may cause side effects to become worse.
  • Breast cancer, prolactin-dependent or
  • Glaucoma, narrow-angle or
  • Hyperlipidemia (high cholesterol or fat in the blood) or
  • Hyperprolactinemia (high prolactin in the blood) or
  • Liver disease or
  • Paralytic ileus (severe intestinal problem), or history of or
  • Prostatic hypertrophy (enlarged prostate), or history of or
  • Seizures, history of or
  • Urinary retention (problems with passing urine) or history of—Use with caution. This medicine may make these conditions worse.
  • Diabetes or
  • Hyperglycemia (high blood sugar)—Use with caution. This medicine may raise blood sugar levels.
  • Phenylketonuria (PKU, a genetic disease of metabolism)—The orally disintegrating tablet (Zyprexa® Zydis®) contains phenylalanine, which can worsen this condition.

Proper Use

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the medication guide if you do not have one.

If you are using the orally disintegrating tablet (Zyprexa® Zydis®), make sure your hands are dry before you handle the tablet. Do not open the blister pack that contains the tablet until you are ready to take it. Remove the tablet from the blister pack by peeling back the foil and then taking the pill out. Do not push the tablet through the foil. Place the tablet in your mouth. It should melt quickly. After the tablet has dissolved, swallow or take a sip of water.

You may take this medicine with or without food.

Tell your doctor if you smoke tobacco. You might need a different amount of this medicine if you smoke.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your amount is different, do not change it unless your doctor tells you to.

The amount of medicine you take depends on the strength of the treatment. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage forms (orally disintegrating tablets, regular tablets):
  • For treatment of schizophrenia:
    • Adults—At first, 5 to 10 milligrams (mg) once a day. Your doctor may adjust your dose if needed. However, the amount is usually not more than 20 mg per day.
    • Children 13 to 17 years of age—At first, 2.5 or 5 mg once a day. Your doctor may adjust your dose if needed. However, the amount is usually not more than 20 mg per day.
    • Children younger than 13 years of age—Use and dose must be determined by your doctor.
  • For treatment of mania or mixed episodes with bipolar disorder (olanzapine alone):
    • Adults—At first, 10 to 15 milligrams (mg) once a day. Your doctor may adjust your dose if needed. However, the amount is usually not more than 20 mg per day.
    • Children 13 to 17 years of age—At first, 2.5 or 5 mg once a day. Your doctor may adjust your dose if needed. However, the amount is usually not more than 20 mg per day.
    • Children younger than 13 years of age—Use and dose must be determined by your doctor.
  • For treatment of mania or mixed episodes with bipolar disorder (olanzapine with lithium or valproate):
    • Adults—At first, 10 milligrams (mg) once a day. Your doctor may adjust your dose if needed. However, the amount is usually not more than 20 mg per day.
    • Children—Use and dose must be determined by your doctor.
  • For treatment of depression with bipolar disorder (olanzapine with fluoxetine):
    • Adults—At first, 5 milligrams (mg) of olanzapine and 20 mg of fluoxetine every day in the evening. Your doctor may adjust your dose as needed. However, the amount is usually not more than 18 mg of olanzapine and 75 mg of fluoxetine daily.
    • Children 10 to 17 years of age—At first, 2.5 milligrams (mg) of olanzapine and 20 mg of fluoxetine once a day in the evening. Your doctor may adjust your dose as needed. However, the amount is usually not more than 12 mg of olanzapine and 50 mg of fluoxetine daily.
    • Children younger than 10 years of age—Use and dose must be determined by your doctor.
  • For treatment-resistant depression (olanzapine with fluoxetine):
    • Adults—At first, 5 milligrams (mg) of olanzapine and 20 mg of fluoxetine every day in the evening. Your doctor may adjust your dose as needed. However, the amount is usually not more than 18 mg of olanzapine and 75 mg of fluoxetine daily.
    • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and return to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how to dispose of any medicine you do not use.

Precautions

Your doctor must check your or your child’s progress regularly to ensure this medicine works properly. Blood tests may be needed to check for unwanted effects.

Olanzapine may cause some people to be agitated, irritable, or display other abnormal behaviours. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. Tell your doctor immediately if you or your caregiver notice any of these unwanted effects.

This medicine may cause a condition called drug reaction with eosinophilia and systemic symptoms (DRESS). Call your doctor immediately if you have a rash, red, swollen skin, fever, chills, cough, trouble breathing, swollen glands, or unusual bleeding, bruising, or weakness after using this medicine.

This medicine may increase the amount of sugar in your blood. Check with your doctor immediately if you have increased thirst or urination. If you or your child have diabetes, you may notice a change in the results of your urine or blood sugar tests. If you have any questions, check with your doctor.

This medicine may increase your cholesterol and fats in the blood. If this condition occurs, your doctor may give you or your child some drugs to lower cholesterol and fats in the blood.

This medicine may increase your weight. Your doctor may need to check your or your child’s weight regularly while using this medicine.

Check with your doctor immediately if you have difficulty breathing, a fast heartbeat, a high fever, high or low blood pressure, increased sweating, loss of bladder control, seizures, severe muscle stiffness, unusually pale skin, or tiredness. These could be symptoms of a serious neuroleptic malignant syndrome (NMS).

This medicine may cause tardive dyskinesia (a movement disorder). Check with your doctor immediately if you or your child have lip smacking or puckering, puffing of the cheeks, rapid or worm-like movements of the tongue, uncontrolled chewing movements, or uncontrolled movements of the arms and legs.

Dizziness, lightheadedness or fainting may occur, especially when you get up from a lying or sitting position. Getting up slowly may help. If this problem continues or gets worse, check with your doctor.

This medicine can temporarily lower the number of white blood cells in your blood, increasing the chance of infection. If you can, avoid people with disorders. Check with your doctor immediately if you or your child think you are getting an infection, fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.

Olanzapine may cause drowsiness, trouble with thinking, controlling body movements, or situations with your vision, which may lead to falls, fractures or other injuries. Make sure you know how you react to this medicine before you drive, use machines, or do other jobs that require you to be alert, well-coordinated, or able to think or see well.

This medicine may add to the effects of alcohol and another central nervous system (CNS) depressants (medicines that make you drowsy or less alert). Some CNS depressants are antihistamines or medications for allergies or colds, sedatives, tranquillizers, or sleeping medicines, prescription pain medicines or narcotics, medicines for seizures or barbiturates, muscle relaxants, or anaesthetics, including some dental drugs. Check with your doctor before taking any CNS depressants while you are taking this medicine.

This medicine may make it more difficult for your body to cool down. It might reduce how much you sweat. Your body could get too hot if you do not sweat enough. You might feel dizzy, weak, tired, or confused if your body gets too hot. You might vomit or have an upset stomach. Do not get too hot while you are exercising. Avoid very hot places. Call your doctor if you are too hot and can not cool down.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or non-prescription (over-the-counter [OTC]) medicines) and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur, they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  1. Bloating or swelling of the face, arms, hands, lower legs, or feet
  2. blurred vision
  3. change in vision
  4. change in walking and balance
  5. clumsiness or unsteadiness
  6. difficulty with speaking
  7. difficulty with swallowing
  8. drooling
  9. impaired vision
  10. inability to sit still
  11. loss of balance control
  12. mask-like face
  13. muscle trembling, jerking, or stiffness
  14. Need to keep moving
  15. rapid weight gain
  16. restlessness
  17. shuffling walk
  18. slowed movements
  19. slurred speech
  20. stiffness of the arms and legs
  21. tic-like (jerky) movements of the head, face, mouth, and neck
  22. tingling of the hands or feet
  23. trembling or shaking of the fingers, hands, feet, legs, or arms
  24. twisting movements of the body
  25. uncontrolled movements, especially of the face, neck, and back
  26. unusual weight gain or loss

Less common

  1. Bladder pain
  2. bloody or cloudy urine
  3. bruising
  4. burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
  5. chest pain
  6. difficult or laboured breathing
  7. difficult, burning, or painful urination
  8. dizziness
  9. excessive muscle tone
  10. frequent urge to urinate
  11. headache
  12. inability to move the eyes
  13. increased blinking or spasms of the eyelid
  14. itching of the vagina or genital area
  15. lack of coordination
  16. large, flat, blue, or purplish patches on the skin
  17. loss of bladder control
  18. loss of memory
  19. lower back or side pain
  20. muscle tension or tightness
  21. nervousness
  22. pain during sexual intercourse
  23. pounding in the ears
  24. problems with memory
  25. the rhythmic movement of the muscles
  26. slow, fast, pounding, or irregular heartbeat or pulse
  27. Speaking is less clear than usual.
  28. sticking out the tongue
  29. thick, white vaginal discharge with no odour or with a mild odour
  30. tightness in the chest
  31. twitching
  32. uncontrolled twisting movements of the neck, trunk, arms, or legs
  33. unusual or incomplete body or facial movements
  34. weakness of the arms and legs

Some side effects may occur that usually do not need medical attention. These side effects may disappear during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Acid or sour stomach
  2. back pain
  3. belching
  4. change in personality
  5. difficulty having a bowel movement (stool)
  6. discouragement
  7. feeling sad or empty
  8. fever
  9. heartburn
  10. increased appetite
  11. increased cough
  12. indigestion
  13. lack of appetite
  14. lack or loss of strength
  15. loss of interest or pleasure
  16. runny nose
  17. sneezing
  18. stomach discomfort, upset, or pain
  19. stuffy nose
  20. thirst
  21. trouble sleeping
  22. trouble with concentrating
  23. watering of the mouth

Less common

  1. Blemishes on the skin
  2. body aches or pain
  3. chills
  4. cold sweats
  5. congestion
  6. cough
  7. dry skin
  8. dryness or soreness of the throat
  9. false or unusual sense of well-being
  10. heavy menstrual bleeding (periods)
  11. hoarseness
  12. joint pain
  13. lack of feeling or emotion
  14. leg cramps
  15. pain in the arms or legs
  16. pimples
  17. sweating
  18. tender, swollen glands in the neck
  19. uncaring feelings
  20. voice change
  21. vomiting

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